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Midfielders Dele Alli and Jesse Lingard have been left Gareth Southgate’s group to the Euro 2020 qualifiers away into the Czech Republic and Bulgaria.
Although striker Tammy Abraham, his Chelsea team-mate, is also picked, a first call-up is for defender Fikayo Tomori.
Manchester City right-back Kyle Walker has been omitted.
England play with the Czechs on Bulgaria and 11 October on 14 October.
Liverpool midfielder Alex Oxlade-Chamberlain overlooks, although everton midfielder Fabian Delph was remembered.
Injured Manchester United right-back Aaron Wan-Bissaka is not included.
“There have been some tough decisions to make,” said Southgate. “It is an exciting group, with players very much in form.
“There is still an emphasis on the evolution of younger players but surrounded by good experience”
Abraham, 22, had said he had”never made a decision yet” on his global future because he is also eligible to play for Nigeria, using just played for England in two friendlies rather than a competitive game.
Whereas the same applies to Tomori who played for Canada in Under-20 level if he performs against Bulgaria or even the Czechs, he won’t be able to switch allegiance.
“It’s not ethically right to give somebody a cap only so they can’t play for somebody else,” said Southgate.
“He and Fikayo Tomori are both on merit and have become part of our junior system right through, thus we see them as English players and they have a enormous desire to play England at senior level.”
Abraham has netted eight goals in 10 matches in all competitions for Chelsea so much this year and is combined second at the Premier League’s top-scorers’ chart.
“This was a rather simple decision [to select him] as he’s the major British goalscorer in the group,” said Southgate.
Abraham has been part of this England Under-21 squad in the European Championship, also played for England in draws in 2017 with Germany and Brazil this summer.
“We put him to the squad quite youthful, when we were altering the complexion of what exactly we were doing,” added Southgate.
“This was somewhat premature for him because of the chance given to him by Frank Lampard in Chelsea, we have brought him back in.
“That is currently a great opportunity for Tammy.”
Goalkeepers: Tom Heaton (Aston Villa), Jordan Pickford (Everton), Nick Pope (Burnley)
Defenders: Trent Alexander-Arnold (Liverpool), Ben Chilwell (Leicester), Joe Gomez (Liverpool), Michael Keane (Everton), Harry Maguire (Manchester United), Tyrone Mings (Aston Villa), Danny Rose (Tottenham), Fikayo Tomori (Chelsea), Kieran Trippier (Atletico Madrid)
Midfielders: Ross Barkley (Chelsea), Fabian Delph (Everton), Jordan Henderson (Liverpool), James Maddison (Leicester), Mason Mount (Chelsea), Declan Rice (West Ham), Harry Winks (Tottenham)
Forwards: Tammy Abraham (Chelsea), Harry Kane (Tottenham), Marcus Rashford (Manchester United), Jadon Sancho (Borussia Dortmund), Raheem Sterling (Manchester City), Callum Wilson (Bournemouth)
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